Works to block 6 key inflammatory mediators 

FLONASE® Allergy Relief does more to block the allergic cascade

FLONASE® Allergy Relief works to block 6 key inflammatory mediators, not just histamine*1-3:

  • histamine
  • cytokines
  • leukotrienes
  • chemokines
  • prostaglandins
  • tryptases

The allergic cascade involves more than just histamine

The body’s immune response to allergens includes a series of early- and late-phase reactions—the allergic cascade.4 While a number of allergic mediators are involved in this cascade, single-ingredient, oral, nonsedating antihistamines (NSAs) only block histamine.1,4

While NSAs must be absorbed systemically before they can act on the nasal mucosa, FLONASE® Allergy Relief is delivered locally, acts directly in the nasal passage, and relieves nasal congestion; single-ingredient NSAs do not.1-3 In addition to relieving nasal allergy symptoms, FLONASE® Allergy Relief is the first and only OTC intranasal corticosteroid (INS) indicated to relieve nasal allergy symptoms and itchy, watery eyes.4-8 24-hour relief starts with the first dose for some patients.5,6

Ask your patients how well their allergic rhinitis symptoms are controlled

A national survey showed that 55% of nasal allergy sufferers were not fully satisfied with their current allergy medication.9 Some may need to try another nasal allergy treatment to see if they can get better relief.

*Mechanism vs. most OTC allergy pills. FLONASE® acts on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.


Global environmental changes are causing allergic rhinitis to increase in incidence and prevalence10

These include:

  • Climate changes increase CO2 levels worldwide, which in turn, affect plants10
    • Earlier bloom times, where spring pollen season begins 6 days earlier than it did in the 1960s11
    • Longer growing season, which lengthens pollen season (some reports state an increased duration of 13-27 days)12
    • Bigger, stronger plants that generate increased pollen production (estimated future increases of 90% are predicted)10

FLONASE® Allergy Relief can help relieve symptoms from today's allergic rhinitis

FLONASE® Allergy Relief can be used once daily for up to 6 months as part of a regular nasal allergy treatment regimen to manage seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) symptoms whenever they arise.5 24-hour relief starts with the first dose for some patients.5,6

If use of FLONASE® Allergy Relief is needed beyond 6 months, patients should consult their healthcare professional.5

The growth rate of some children may be slower using this product. Children should use FLONASE® for the shortest amount of time necessary to achieve symptom relief. Patients or caregivers should contact their healthcare professional if a child needs to use FLONASE® for longer than 2 months in a year. Only 1 spray should be used in each nostril daily and an adult should supervise use.

Frequent nasal allergies demand better management and control10

Ongoing exposure to increased allergens in the environment is a key factor to a rise in chronic allergic rhinitis, an increase in the severity of nasal allergy symptoms, and corresponding deterioration in patients’ quality of life.13,14 Surveys show that:

  • More than one-third of nasal allergy sufferers report that they are less effective at work15
  • 93% report impaired classroom performance16
  • More than 45% of patients report feeling tired17
  • 77% of nasal allergy sufferers have trouble sleeping17

FLONASE® Allergy Relief can help improve symptoms of allergic rhinitis that affect quality of life

  • In clinical trials, patients treated with FLONASE® Allergy Relief experienced more symptom-free days than those patients treated with loratadine14
  • Patients also reported an improved sense of well-being and a superior impact on attendance and performance at work, school, home, and in daily leisure/recreational activities as compared with patients treated with placebo and antihistamine5
  • Effective symptom control with FLONASE® Allergy Relief can also help relieve the tiredness and irritability associated with nasal allergies18,19


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  2. Hallgren J, Pejler G. Biology of mast cell tryptase: an inflammatory mediator. FEBS J. 2006;273(9):1871-1895.
  3. Broide D. The pathophysiology of allergic rhinoconjunctivitis. Allergy Asthma Proc. 2007;28(4):398-403.
  4. IGE’s role in allergic asthma. Asthma and Allergy Foundation of America website. Accessed June 2, 2014.
  5. Data on file. GlaxoSmithKline. 2014.
  6. FLONASE Drug Facts Label.
  7. Nasacort Drug Facts Label.
  8. WebMD. Can nasal steroids ease allergy symptoms? Accessed October 14, 2014.
  9. New survey reveals many patients want more from their allergy medication. Asthma and Allergy Foundation of America website. Accessed December 3, 2014.
  10. Beggs PJ. Impacts of climate change on aeroallergens: past and future. Clin Exp Allergy. 2004;34(10):1507-1513.
  11. Menzel A, Fabian P. Growing season extended in Europe. Nature. 1999;37:659.
  12. Ziska L, Knowlton K, Rogers C, et al. Recent warming by latitude associated with increased length of ragweed pollen season in central North America. Proc Natl Acad Sci USA. 2011;108(10):4248-4251.
  13. D’Amato G. Urban air pollution and plant-derived respiratory allergy. Clin Exp Allergy. 2000;30(5):628-636.
  14. Géhanno P, Desfougeres JL. Fluticasone propionate aqueous nasal spray compared with oral loratadine in patients with seasonal allergic rhinitis. Allergy. 1997;52(4):445-450.
  15. Blanc PD, Trupin L, Eisner M, et al. The work impact of asthma and rhinitis: findings from a population-based survey. J Clin Epidemiol. 2001;54(6):610-618.
  16. Tanner LA, Reilly M, Meltzer EO, Bradford JE, Mason J. Effect of fexofenadine HCl on quality of life and work, classroom, and daily activity impairment in patients with seasonal allergic rhinitis. Am J Managed Care. 1999;5(4, suppl):S235-S247.
  17. Brooks M. Allergic rhinitis a significant burden. Medscape website. Published March 30, 2011. Accessed March 27, 2014.
  18. Craig TJ, Teets S, Lehman EB, Chinchilli VM, Zwillich C. Nasal congestion secondary to allergic rhinitis as a cause of sleep disturbance and daytime fatigue and the response to topical nasal corticosteroids. J Allergy Clin Immunol. 1998;101(5):633-637.
  19. Sardana N, Craig TJ. Congestion and sleep impairment in allergic rhinitis. Asian Pac J Allergy Immunol. 2011;29(4):297-306.